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Smartox/ω芋螺毒素MVIIA，一种有效的钙通道阻滞剂v2.2/08CON001-00500/0.5mg
Smartox/ω芋螺毒素MVIIA，一种有效的钙通道阻滞剂v2.2/08CON001-00500/0.5mg
商品编号：
08CON001-00500
品牌：
smartox-biotech
市场价：
¥3120.00
美元价：
2400.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
ωconotoxinMVIIA (omegaconotoxinMVIIA) hasbeenisolatedfromthevenomoftheconeConusmagus.Omega-conotoxinsactatpresynapticmembranes,theybindandblockvoltage-sensitivecalciumchannels(VSCC). ωconotoxinMVIIA blocks N-typevoltage-gatedcalciumchannels(Cav2.2/CACNA1B). ωconotoxinMVIIA isavailableasanalgesicdrugunderthenamePrialt®.Itblocksacutepaininpatientswhonolongerobtainrelieffromopiatedrugs.Itis100to1.000timesmorepotentthanmorphine.Thistoxinblockscalciumchannelsanddisablesnervesthattransmitpainsignals.
Description:
AAsequence: Cys1-Lys-Gly-Lys-Gly-Ala-Lys-Cys8-Ser-Arg-Leu-Met-Tyr-Asp-Cys15-Cys16-Thr-Gly-Ser-Cys20-Arg-Ser-Gly-Lys-Cys25-NH2
Disulfidebonds: Cys1-Cys16,Cys8-Cys20 andCys15-Cys25
Length(aa): 25
Formula: C102H172N36O32S7
MolecularWeight: 2639.18Da
Appearance:Whitelyophilizedsolid
Solubility: waterandsalinebuffer
CASnumber: [107452-89-1]Source: Synthetic
Purityrate: >97%
Reference:
Ziconotide:neuronalcalciumchannelblockerfortreatingseverechronicpain
Ziconotide(PRIALT)isaneuroactivepeptideinthefinalstagesofclinicaldevelopmentasanovelnon-opioidtreatmentforseverechronicpain.Itisthesyntheticequivalentofomega-MVIIA,acomponentofthevenomofthemarinesnail,Conusmagus.Themechanismofactionunderlyingziconotide’stherapeuticprofilederivesfromitspotentandselectiveblockadeofneuronalN-typevoltage-sensitivecalciumchannels(N-VSCCs).DirectblockadeofN-VSCCsinhibitstheactivityofasubsetofneurons,includingpain-sensingprimarynociceptors.Thismechanismofactiondistinguishesziconotidefromallotheranalgesics,includingopioidanalgesics.Infact,ziconotideispotentlyanti-nociceptiveinanimalmodelsofpaininwhichmorphineexhibitspooranti-nociceptiveactivity.Moreover,incontrasttoopiates,tolerancetoziconotideisnotobserved.Clinicalstudiesofziconotideinmorethan2,000patientsrevealimportantcorrelationstoziconotide’snon-clinicalpharmacology.Forexample,ziconotideprovidessignificantpainrelieftoseverechronicpainsuffererswhohavefailedtoobtainrelieffromopiatetherapyandnoevidenceoftolerancetoziconotideisseeninthesepatients.Contingentonregulatoryapproval,ziconotidewillbethefirstinanewclassofneurologicaldrugs:theN-typecalciumchannelblockers,orNCCBs.Itsnovelmechanismofactionasanon-opioidanalgesicsuggestsziconotidehasthepotentialtoplayavaluableroleintreatmentregimensforseverechronicpain.Ifapprovedforclinicaluse,ziconotidewillfurthervalidatetheneuroactivevenompeptidesasasourceofnewandusefulmedicines.
Miljanich,G.P.(2004)Ziconotide:neuronalcalciumchannelblockerfortreatingseverechronicpain,CurrMedChem.PMID:15578997
NeuronalcalciumchannelantagoNISTs.Discriminationbetweencalciumchannelsubtypesusingomega-conotoxinfromConusmagusvenom
Theomega-conotoxinsfromthevenomoffish-huntingconesnailsareprobablythemostusefulofpresentlyavailableligandsforneuronalCachannelsfromvertebrates.Twoofthesepeptidetoxins,omega-conotoxinsMVIIAandMVIIBfromthevenomofConusmagus,werepurified.Theaminoacidsequencesshowsignificantdifferencesfromomega-conotoxinsfromConusgeographus.Totalsynthesisofomega-conotoxinMVIIAwasachieved,andBIOLOGicallyactiverADIolabeledtoxinwasproducedbyiodination.Althoughomega-conotoxinsfromC.geographus(GVIA)andC.magus(MVIIA)appeartocompeteforthesamesitesinmammalianbrain,inamphibianbrainthehigh-affinitybindingofomegaconotoxinMVIIAhasnarrowerspecificity.Inthissystem,itisdemonstratedthatacombinationoftwoomega-conotoxinscanbeusedforbiochemicallydefiningreceptorsubtypesandsuggestedthatthesecorrespondtosubtypesofneuronalCa2+channels.Olivera,B.M.,etal.(1987)Neuronalcalciumchannelantagonists.Discriminationbetweencalciumchannelsubtypesusingomega-conotoxinfromConusmagusvenom,Biochemistry.PMID:2441741
Pharmacotherapeuticpotentialofomega-conotoxinMVIIA(SNX-111),anN-typeneuronalcalciumchannelblockerfoundinthevenomofConusmagus
BowersoxSS,LutherR.Pharmacotherapeuticpotentialofomega-conotoxinMVIIA(SNX-111),anN-typeneuronalcalciumchannelblockerfoundinthevenomofConusmagus. Toxicon. PMID: 9792182
品牌介绍
Smartox Biotechnology 是全球唯一一家专门生产动物毒液多肽毒素，用于细胞离子通道功能研究的生物医药公司。多肽毒素在生物制药领域具有重要的使用价值。Smartox Biotechnology 于 2009 年由来自 Grenoble 神经科学研究所 (Grenoble Institute of Neuroscience) 的 Michel de waard 博士创立, Smartox Biotechnology 专门研究动物毒液，制作合成多种毒液中的多肽成分（常称为毒素）。 De Waard 博士研究离子通道与毒素多肽的关系，尤其是鉴定、开发毒素多肽作为治疗性分子或细胞穿透肽 (cell penetrating peptides, CPP) 。其研究团队在毒液分离，药理性活性肽鉴定、富半胱氨酸肽定性、制作和优化等方面具有独特、丰富的经验。 2010 年， Smartox Biotechnolgy 被法国研究部 (Ministry of Research) 授予“新兴企业 OSEO 奖 (OSEO prize for emerging businesses) ”。
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