Lys-conopressinGisaconopeptidethatwasisolatedfromconusimperialis.Thisvasopressin-likepeptideinducesscratchingandgroomingbehaviorwheninjectedintomice.
Description:
AAsequence: Cys1-Phe-Ile-Arg-Asn-Cys6-Pro-Lys-Gly-NH2
(DisulfidebondbetweenCys1-Cys6)
Length(aa): 9
Formula: C44H70N15O10S2
MolecularWeight: 1033.26Da
Appearance: Whitelyophilizedsolid
Solubility: waterandsalinebuffer
CASnumber:
Source: Synthetic
Purityrate: >97%
Reference:
IsolationofLys-conopressin-Gfromthevenomoftheworm-huntingsnail,Conusimperialis
Vasopressinhomologshavepreviouslybeenisolatedfromthevenomoffish-huntingconesnails.Weinvestigatedwhetheravasopressin-likepeptideisfoundintheworm-hunter,Conusimperialis.Usingi.c.injectionsinmice,weisolatedapeptidefromthevenomofC.imperialiswhichinducesscratchingandgroomingbehaviorcharacteristicoftheconopressins.BiochemicalcharacterizationshowedthatthispeptideisidenticaltoLys-conopressin-G.Theresultsledustospeculatethatthevasopressin-likepeptidesinConusvenomsmaybeexamplesofanevolvingconversionofendogenouspeptidesforspecializedvenomuses.
NielsenDB, etal. (1994)IsolationofLys-conopressin-Gfromthevenomoftheworm-huntingsnail,Conusimperialis.Toxicon. PMID: 7940591
Characterizationofpeptidesfromconusgeographusandconusstriatusvenoms.
Thevasopressin-oxytocinfamilyofpeptidesisofveryancientlineage,foundinorganismsasdiverseashydraandman.Althoughthesepeptideshavebeenintensivelystudiedinvertebrates,thepresumablymoreextensiveinvertebrateserieswasdefinedprimarilybyimmunologicalmethods.Inthisreport,wedescribethepurificationandstructuresoftwopeptidesofthevasopressin-oxytocinfamilyfrommolluscs(“Conopressins”),whichwerefoundinthevenomoffish-huntingmarinesnailsofthegenusConus.TheBIOLOGicalactivityobservedwhenthetwosnailpeptidesareinjectedintracerebrallyintomiceisverysimilartothatelicitedbythevertebrateneurohypophysealhormonesandpresumablyreflectstheiractionsuponacommonreceptorinthebrain.Thesequencesofthepurifiedpeptidesrevealuniquefeaturesnotfoundinthevertebratepeptideseries,mostnotablyanadditionalpositivecharge.Thesearethefirstmembersoftheinvertebrateseriesofthevasopressin-oxytocinfamilytobecharacterizedbiochemically.Thesequencesofthesepeptidesare:fromConusgeographusvenom,Lys-conopressin-G,Cys-Phe-Ile-Arg-Asn-Cys-Pro-Lys-Gly-NH2;andfromConusstriatusvenom,Arg-conopressin-S,Cys-Ile-Ile-Arg-Asn-Cys-Pro-Arg-Gly-NH2.
LourdesJ. etal.(1987) Characterizationofpeptidesfromconusgeographusandconusstriatusvenoms. JBiolChem. PMID: 3680228
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