Smartox//NMB001-01000/1mg
商品编号：
NMB001-01000
品牌：
smartox-biotech
市场价：
¥6864.00
美元价：
5280.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
NMB-1(Noxiousmechanosensationblocker1)isananalogueofapeptideisolatedfromamarineconesnail.This19aminoacidpeptidehasshowna30foldselectivityininhibitingslowlyadaptingmechanicallyactivatedcurrentsoverrapidlyadaptingones.ItisaninterestingtooltodistinguishbetweenRAandSAcurrents.NMB-1significantlyblocksSAcurrentsat1µMinsensoryneuronscontrarytoGsMTx4.SomeresultssuggestthatNMB-1couldalsoblockmechanosensitiveionchannelsincochlearhaircellsat5µM.
SmartoxBiotechnologyispleasedtobethefirstcompanyofferingthisresearchtool.
Description:
AAsequence:Phe-Asn-Trp-Arg-Cys-Cys-Leu-Ile-Pro-Cys-Arg-Arg-Asn-His-Lys-Lys-Phe-Phe-Cys-NH2
Disulfidebonds:Cys5-Cys19andCys6-Cys10
Length(aa):19
Formula:C111H164N36O21S4
MolecularWeight: 2467.03Da
Appearance:Whitelyophilizedsolid
Solubility:aqueousbuffer
CASnumber:notavailable
Source:Synthetic
Purityrate:>95%
Reference:
High-ThresholdMechanosensitiveIonChannelsBlockedbyaNovelConopeptideMediatePressure-EvokedPain
Littleisknownaboutthemolecularbasisofsomatosensorymechanotransductioninmammals.Wescreenedalibraryofpeptidetoxinsforeffectsonmechanicallyactivatedcurrentsincultureddorsalrootganglionneurons.Oneconopeptideanalogue,termedNMB-1fornoxiousmechanosensationblocker1,selectivelyinhibits(IC501mM)sustainedmechanicallyactivatedcurrentsinasubsetofsensoryneurons.BiotinylatedNMB-1retainsactivityandbindsselectivelytoperipherinpositivenociceptivesensoryneurons.TheselectivityofNMB-1wasconfirmedbythefactthatithasnoinhibitoryeffectsonvoltage-gatedsodiumandcalciumchannels,orligand-gatedchannelssuchasacid-sensingionchannelsorTRPA1channels.Conversely,thetarantulatoxin,GsMTx-4,whichinhibitsstretch-activatedionchannels,hadnoeffectsonmechanicallyactivatedcurrentsinsensoryneurons.Inbehavioralassays,NMB-1inhibitsresponsesonlytohighintensity,painfulmechanicalstimulationandhasnoeffectsonlowintensitymechanicalstimulationorThermosensation.Unexpectedly,NMB-1wasfoundtoalsobeaninhibitorofrapidFM1-43loADIng(ameasureofmechanotransduction)incochlearhaircells.Thesedatademonstratethatpharmacologicallydistinctchannelsrespondtodistincttypesofmechanicalstimuliandsuggestthatmechanicallyactivatedsustainedcurrentsunderlienoxiousmechanosensation.NMB-1thusprovidesanoveldiagnostictoolforthemoleculardefinitionofchannelsinvolvedinhearingandpressure-evokedpain.DrewLJ.,etal.(2007)PLoSONE
Molecularmechanismsofmechanotransductioninmammaliansensoryneurons
Thesomatosensorysystemmediatesfundamentalphysiologicalfunctions,includingthesensesoftouch,painandproprioception.Thisvarietyoffunctionsismatchedbyadiversearrayofmechanosensoryneuronsthatrespondtoforceinaspecificfashion.Mechanotransductionbeginsatthesensorynerveendings,whichrapidlytransformmechanicalforcesintoelectricalsignals.Progresshasbeenmadeinestablishingthefunctionalpropertiesofmechanoreceptors,butithasbeenremarkablydifficulttocharacterizemechanotranducerchannelsatthemolecularlevel.However,inthepastfewyears,newfunctionalassayshaveprovidedinsightsintothebasicpropertiesandmolecularidentityofmechanotransducerchannelsinmammaliansensoryneurons.Therecentidentificationofnovelfamiliesofproteinsasmechanosensingmoleculeswillundoubtedlyaccelerateourunderstandingofmechanotransductionmechanismsinmammaliansomatosensation.DelmasP.,etal.(2011)Nature
品牌介绍
Smartox Biotechnology 是全球唯一一家专门生产动物毒液多肽毒素，用于细胞离子通道功能研究的生物医药公司。多肽毒素在生物制药领域具有重要的使用价值。Smartox Biotechnology 于 2009 年由来自 Grenoble 神经科学研究所 (Grenoble Institute of Neuroscience) 的 Michel de waard 博士创立, Smartox Biotechnology 专门研究动物毒液，制作合成多种毒液中的多肽成分（常称为毒素）。 De Waard 博士研究离子通道与毒素多肽的关系，尤其是鉴定、开发毒素多肽作为治疗性分子或细胞穿透肽 (cell penetrating peptides, CPP) 。其研究团队在毒液分离，药理性活性肽鉴定、富半胱氨酸肽定性、制作和优化等方面具有独特、丰富的经验。 2010 年， Smartox Biotechnolgy 被法国研究部 (Ministry of Research) 授予“新兴企业 OSEO 奖 (OSEO prize for emerging businesses) ”。
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